This pathway, known as the “anti-inflammatory cholinergic reflex,” is mediated by the activation of the alpha-7 nicotinic acetylcholine (ACh) receptor (α7nAChR) in macrophages (Pavlov and Tracey, 2004), and linked to the genesis/development of atherosclerosis (Chen et al., 2016). This evidence concerns the gene CHRNA7 and atherosclerosis.