We recently showed that male ApoE KO rats as young as 6–9-weeks-old have greater endothelial dysfunction in their pulmonary arteries than Sprague Dawley rats after a similar simulated dive protocol (absolute pressure of 600 kPa and decompression of 50 kPa/min), due to altered NO-dependent signaling (Berenji Ardestani et al., 2019). Here, APOE is linked to endothelial dysfunction.