It is also worth stating that many specific ECM/mechanosensing-related genes whose expression was downregulated in TNF-dependent manner with exercise have been linked previously to AF and ECM remodeling, including Comp (Zou et al., 2018; Thomas et al., 2019), Thbs2 (Yang et al., 2000), Ltbp1 and Fbn1 (Zhang et al., 2020; Figure 3 and Table 1). This evidence concerns the gene COMP and atrial fibrillation.