Indeed, Pak1 regulates exercise-induced cardiac hypertrophy (Davis et al., 2015), which aligns nicely with our 2 day atrial analyses showing exercise-induced upregulation of Flna (filamen A), a cytoprotective protein that is upregulated with mechanical stress (D’Addario et al., 2003) and is essential for actin/cytoskeletal dynamics (Vadlamudi et al., 2002) through interdependent p38- (D’Addario et al., 2002) and Pak1-mediated signaling (Zhang et al., 1995; Shifrin et al., 2012). The gene discussed is FLNA; the disease is cardiac hypertrophy.