The role of MMPs in stroke-induced BBB dysfunction was evidenced by Shuai et al., who found that stroke results in decreased ZO-1 expression and translocation of ZO-1 from the cell junctions to the cytoplasm, which occurs due to increased MMP-2/9 and caveolin-1 expression (Zhang et al., 2018). The gene discussed is CAV1; the disease is Stroke.