Since mice globally deficient for Cx40 are hypertensive due to an abrogated feedback of pressure on renin release (Wagner et al., 2007, 2010; Schweda et al., 2009), hypertension might be a causative factor in impairing the EDH-type dilation through modifying myoendothelial junctions by an alteration of connexin expression (Figueroa et al., 2006; Meens et al., 2013). This evidence concerns the gene GJA5 and hypertensive disorder.