EP300 and cardiac hypertrophy: Additionally, these results are in line with previous reports that PRMT5 protected against cardiac hypertrophy by methylating GATA4 to hamper p300-mediacted GATA acetylation (Chen et al., 2014), and by symmetric di-methylating Histone H4R3 via regulation of Filip1L/β-catenin (Cai et al., 2020).