KLF5 expression and activity are altered in many cancer types including breast (Takagi et al., 2012), cervical (Ma et al., 2017), colorectal (Ghaleb and Yang, 2008), lung (Li et al., 2014), pancreatic (Li et al., 2019) and thyroid cancer (Ma et al., 2018). The gene discussed is KLF5; the disease is cancer.