NLRP3 and dermatitis: Other studies highlighted the anti-inflammatory role of Nrf2 signaling in reducing the levels of IL-1β and IL-6 to alleviate skin inflammation (Saw et al., 2010) besides suppressing the activation of inflammatory NF-κB and NLRP3 pathways (Bulugonda et al., 2017; Helou et al., 2019; Hennig et al., 2020).