Among them, advanced glycosylated end product-glycosylated end product receptor (AGE-RAGE), phosphatidylinositol 3 kinase/protein kinase (PI3K/Akt), focal adhesion (FA), Toll-like receptor (TLR), nuclear transcription factor (NF-κB) and some infectious disease such as hepatitis B, malaria, tuberculosis, human cytomegalovivirus infection, cancer pathways as well as cell apoptosis pathways were highly involved. The gene discussed is NFKB1; the disease is hepatitis B virus infection.