Among them, advanced glycosylated end product-glycosylated end product receptor (AGE-RAGE), phosphatidylinositol 3 kinase/protein kinase (PI3K/Akt), focal adhesion (FA), Toll-like receptor (TLR), nuclear transcription factor (NF-κB) and some infectious disease such as hepatitis B, malaria, tuberculosis, human cytomegalovivirus infection, cancer pathways as well as cell apoptosis pathways were highly involved. This evidence concerns the gene NFKB1 and infectious disease.