PPARA and nicotine dependence: Other laboratories have confirmed the interaction between α7-nAChRs and PPARα in different settings: Donvito et al. (2017) observed that the antinociceptive effects of α7-nAChR agonists were mediated by a rise in PEA and activation of PPARα and Jackson et al. (2017) confirmed that PPARα is involved in the effects mediated by α7-nAChR agonists in nicotine dependence.