TRPV1 and hyperinsulinemic hypoglycemia, familial, 4: In conclusion, chronic tear deficiency sensitizes the TRPV1-mediated response in LB-HT cold-sensitive and cold-insensitive polymodal nerves in the cornea, which may serve as therapeutic targets of spontaneous dry eye discomfort and hyperalgesia to nociceptive stimuli in aqueous-deficient dry eyes.