For example, α-synuclein (SNCA), which might be involved in neuronal functions through facilitating SNARE-dependent vesicle fusion process, has been shown mutated in familial PD cases; point mutations in the SNCA gene such as A53T (Polymeropoulos et al., 1997), A30P (Krüger et al., 1998), and G51D (Lesage et al., 2013) could result in early-onset PD among family members. The gene discussed is SNCA; the disease is Parkinson disease.