NFE2L2 and Cognitive impairment: DHEA had antiepileptic effects and alleviated cognitive deficits associated with epileptic activity. DHEA can inhibit lipid peroxidation, protein oxidation, and Na+, K+-ATpase activity in epilepsy. DHEA can reduce oxidative stress and apoptosis of epilepsy iron-induced by activating the NRF2/ARE signaling pathway.