It is also important to note that chronic exposure to alcohol and alcohol dependence lead to dysregulation of several neural circuits, such as the mesolimbic dopamine and the corticotropin releasing factor systems (Diana et al., 1993; Weiss et al., 1996; Volkow et al., 2007; Roberto et al., 2010; Marty and Spigelman, 2012; Liang et al., 2014a, b; Herman et al., 2016; Marty et al., 2020), which could alter the beneficial effects of GLP-1 analogs observed in non-dependent subjects – an important question that should be explored in future studies. Here, GCG is linked to alcohol dependence.