MAPT and Atrophy: Since more and more studies are confirming a qualitative correlation between tau pathology and regional brain atrophy measurements (Harrison et al., 2019; La Joie et al., 2020), our next step will be to characterize this correlation more quantitatively using our coupled model informed by the here presented longitudinal tau PET data on the one hand and longitudinal atrophy measurements from structural MRI of the same patients on the other hand.