To address the importance of MEF2C in osteoclast-mediated pathological bone resorption, we tested the effects of MEF2C deficiency on bone loss in K/BXN serum-induced arthritis.35 K/BxN serum was administrated intra-peritoneally on day 0 and day 2 (Fig. 7a). The gene discussed is MEF2C; the disease is arthritic joint disease.