MEF2C and osteoporosis: Recent studies show that SNPs associated with the MEF2C locus are linked to adult osteoporosis and osteoporotic fractures.6–8 MEF2C is a transcription factor known to be involved in the development of a variety of cells, including muscle, neural, chondroid, immune, and endothelial cells.9–13 MEF2C function is regulated by interaction with other transcription factors and co-activators, and MEF2C undergoes extensive posttranslational modification.