Other, even more rare, types of HAE are not associated with C1-INH deficiency (HAE with normal C1-INH; nC1-INH-HAE, formerly referred to as HAE type 3) and include those associated with mutations in the genes expressing factor XII [5], plasminogen [6], angiopoietin-1 [7], kininogen-1 [8], and myoferlin [9]. The gene discussed is PLG; the disease is hereditary angioedema.