As our data indicated that the EBV genome seems to be a potential driving force for tumorigenesis in NKTCL cells through the LMP1-mediated PGC1β/HKDC1/OGG1 signaling pathway [26, 32, 33] and targeting HKDC1 is especially efficient in NKTCL cells, the development of novel molecules targeting HKDC1 is currently under investigation. This evidence concerns the gene PDLIM7 and extranodal nasal NK/T cell lymphoma.