Subsequently, we investigated the effect of treatments on tumor nodule formation and showed that treatment with shHKDC1/EMP decreased tumor colony formation in the lung to 32% (Fig. 7i) and lung tumor spots to 31%, as indicated by H&E staining (Fig. 7j, k) These effects were shown to be completely and partly reversed by overexpression of SOD2 and OGG1, respectively. This evidence concerns the gene SOD2 and neoplasm.