Although GCB-DLBCL prognosis is generally more favorable than that of ABC-DLBCL, a recent comprehensive analysis of 1001 DLBCL patients revealed that GCB-DLBCL patients who harbor GNA13 mutations and also express high level of BCL2 have an extraordinarily high risk of poor outcomes25. This evidence concerns the gene GNA13 and diffuse large B-cell lymphoma.