To confirm the role of FAM83B in cisplatin resistance, we determined whether FAM83B regulated cisplatin resistance in vivo using Sk-OV-3 cell, animal model showed tumor with FAM83B overexpression inhibited tumor growth after cisplatin treatment, while FAM83B knockdown promoted tumor growth after cisplatin treatment (Fig. 4a). Here, SACK1B is linked to neoplasm.