Regarding the etiologic basis of IR in these patients and considering the role of Zn in insulin signaling mechanisms, the difference between the results of this study with that of Fang et al. could be justified by the fact that in PCOS patients, the effect of Zn and its dietary intake on the metabolic status and components of MetS, which is also linked to insulin resistance, is more pronounced. Here, INS is linked to metabolic syndrome.