Tie2 was shown to be associated with the exocytosis of angiopoietin 2 and enhancement of angiogenesis [10], and KLF4 has long been considered as a key factor in the pathogenesis of CCM [13, 30], and it’s also a regulator of mitochondrial homeostasis [43]. The gene discussed is ANGPT2; the disease is cerebral cavernous malformation.