It is now recognized that most neoplasms diagnosed previously as inflammatory malignant fibrous histiocytomas represent DDLPS with these tumors showing 12q13–15 amplifications or gains, as well as immunohistochemical expression of MDM2 and usually CDK4, and amplification of MDM2 and CDK4 with FISH analysis. The gene discussed is CDK4; the disease is neoplasm.