Our manual approach for the identification of ATLL-relevant mRNAs targeted by the selected miRNAs yielded XPO1, TGFBR1, EGR2, NRAS, SMAD2, PIK3R1, E2F2, TP53INP1, and MAP 3 K1 (supplementary Figure 1). The gene discussed is E2F2; the disease is adult T-cell leukemia/lymphoma.