NOTCH1 and T-cell acute lymphoblastic leukemia: A previous study provided evidence that expression of miR-451 in intracellular Notch1 (ICN1)-expressing bone marrow completely blocked the initiation of T cell acute lymphoblastic leukemia in recipient mice leaving normal T cell development and the generation of nonmalignant ICN1-overexpressing cells intact, indicating that reduced expression of these tumor suppressor genes was required for transformation [78].