Indeed, Tang Z and colleagues proved that MEK, a classic downstream target of EGFR mediated MAPK pathway, is pivotal in maintaining the proteostasis of melanoma cells by phosphorylating and activating HSF1, which means that Ras-MEK-HSF1 and the upstream molecule EGFR may play an important role in the initiation and progression of melanoma [6]. This evidence concerns the gene HSF1 and melanoma.