In addition, both in vivo and in vitro, HSF1-mediated heat shock responses are key events that maintain cellular proteostasis during heat shock and other stress; thus, the normal physiological activities of cells were greatly affected when we entirely blocked the function of HSF1 (in other words, it may cause serious side effects in patients who undergo HSF1 inhibition treatment), and the optimal therapeutic strategy is to weaken the tumor-promoting effect of HSF1 while maintaining its heat shock response function [59]. Here, HSF1 is linked to neoplasm.