HSF1 and cancer: Mentionable, sustained PTSs is inevitable during the cancer initiation and progression [49], and studies have shown that cancer cells are more sensitive to PTSs and have a stronger demand for homeostasis than normal cells [6]; hence, the abnormal activation of HSF1 in cancer cells may emphasize the core role of HSF1 on maintain cell homeostasis during tumorigenesis and progression once again [56, 57].