Considering that the abnormal activation of the normal EGFR pathway and its downstream MAPK/mTOR pathways followed by the KRAS oncogene mutation is essential to the initiation and progression of pancreatic cancer [53–55], these results remind us that EGFR-HSF1 axis might participate in the pancreatic cancer initiation efficiently. This evidence concerns the gene EGFR and pancreatic neoplasm.