After 5 days of recovery, the pathologic morphology of the C mice pancreases had basically returned to a normal acinar structure (there were no ADM or PanINs in the pancreas, only the edema of acinar cells); however, the KC mice pancreases still exhibited a large amount of ADM and even PanINs, and this phenomenon was attenuated by treatment with KRIBB11 compared to that in the vehicles (Fig. 3b and c). The gene discussed is ADM; the disease is keratoconus.