Mentionable, similarly to Liang W and colleagues findings [23], as for the difference of pancreatic cancer cell lines in Fig. 1f, we also detected that HSF1 expression in mutant KRAS cell lines [24] (AsPC-1/KRASG12D, MIAPaCa-2/KRASG12C, PANC-1/KRASG12D, CFPAC-1/KRASG12V) were relative higher than wild-type KRAS cell line [24] (BxPC-3/KRASWT). The gene discussed is HSF1; the disease is familial pancreatic carcinoma.