In this study, compared to normal pancreatic acinar, we found that the starting significant accumulation of HSF1 in the cytoplasmic of human pancreatic ADM structure (Fig. 1a); however, these activated HSF1 were quickly translocated into nucleus of precancerous lesions even as the in early PanINs formation and lasted until invasive PDAC stage, along with an abundant desmoplastic reaction (Fig. 1b), which means HSF1 and its activation may participate in the initiation of human pancreatic cancer. This evidence concerns the gene HSF1 and familial pancreatic carcinoma.