Interestingly, we also found that acute EGF stimulation (30 min) on KC mice pancreatic acinar cells promoted the phosphorylation (the most common activate form) and nuclear translocation of HSF1 Additional file 1: Fig. S3G), however, these effects were inhibited by selumetinib and mTOR inhibitor torkinib (Additional file 1: Fig. S3G). The gene discussed is MTOR; the disease is keratoconus.