HSF1 and familial pancreatic carcinoma: Interestingly, we suggested that the protein level of HSF1 have more clinical significance in pancreatic cancer initiation and progression previously, and as researcher mutually agreed, HSF1 and its target HSPs were key effectors that induce HSRs to maintain cellular proteostasis by perceiving HSSs and other PTSs (Additional file 1: Fig. S3J).