Indeed, by using IHC staining for amylase (acinar marker) and CK19 (ductal marker), we found that KRIBB11 elevated the normal amylase+ acinar area and reduced the abnormal CK19+ ductal area in the KC mice pancreases compared to those of the control (Fig. 2a, e and f); consistently, by using western blotting assay, we found that the CK19 expression and the activation of HSF1 was inhibited by KRIBB11 (represented by the reduction of HSP70) in KC mice pancreas (Fig. 2i), but the amylase expression was upregulated in KRIBB11 treated KC mice compared with vehicle KC mice (Fig. 2i). The gene discussed is HSPA4; the disease is keratoconus.