Specifically, tumor cells express high levels of HSF1 via a variety of methods, for example, inhibiting the ubiquitinated degradation of HSF1 [50], reducing the expression of molecules that compete with HSF1 [51, 52] and stimulating HSF1 activation-related pathways (such as EGFR mediated MAPK pathway [6]). The gene discussed is EGFR; the disease is neoplasm.