Studies have shown that the abnormal activation of the normal EGFR signaling pathway followed by the Kras oncogene mutation is essential to the initiation and progression of pancreatic cancer [58]; nevertheless, we found that a certain number of cells undergo malignant transformation even in the background of EGFR-HSF1 axis inhibition, which indicated the presence of other important components in the initiation of pancreatic cancer. The gene discussed is HSF1; the disease is familial pancreatic carcinoma.