Hence, to further illustrate above doubt, in protein level, we found that compared to pancreatic ductal progenitor cell line hTERT-HPNE (which harbor KRASWT and can reflect the properties of intermediary cells produced during ADM [21, 22]), pancreatic cancer cell lines harbor relative high expression of HSF1 (Fig. 1f). Here, HSF1 is linked to pancreatic neoplasm.