ADM and familial pancreatic carcinoma: Besides, by using the well tumorigenesis model of pancreatic cancer called KC mice (which harbor a pancreas specific mutant KrasG12D oncogene), we found the same phenomenon that there was little HSF1 in normal acinar; however, the accumulation of HSF1 was founded in murine ADM cytoplasmic and in the nucleus of precancerous lesions/invasive PDAC tissues (Fig. 1c).