Indeed, to further demonstrate whether the induction of IRE1α/PERK mediated UPR response or PTSs in pancreatic cancer can active HSF1, similar before, we adopted a well-known gene set from GSEA database (specifically, in REACTOME subsets and named REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONS) to reflect the HSF1 and analyzed the enrichment of this sets in the background of different IRE1α/PERK mRNA expression according to a TCGA PAAD datasets. This evidence concerns the gene EIF2AK3 and familial pancreatic carcinoma.