In this study, by using a transgenic mouse model that can mimic the whole developmental process (from normal acinar cells to invasive PDAC) of pancreatic cancer called LSL-KrasG12D/+; Pdx1-Cre (KC) mice, we demonstrated that the EGFR-HSF1 axis promoted the initiation of pancreatic cancer. The gene discussed is EGFR; the disease is familial pancreatic carcinoma.