These evidence indicate that β-arr1-dependent signaling can engender highly characteristic transcriptomic phenotypes and generate long-lasting effects through the formation of multiprotein transcription complexes, composed by β-arr1/YAP/NFY/mutp53 in breast cancer cells, and by β-arr1/YAP/TEAD/mutp53 in HG-SOC cells. The gene discussed is YAP1; the disease is breast cancer.