Among the GPCR, the endothelin-1 (ET-1) receptors (ET-1R), ETA receptor (ETAR) and ETB receptor (ETBR), are pervasively expressed in many human malignances and their activation confers to tumor cells peculiar malignant traits, orchestrating the signaling network involved in cell proliferation, cell invasion and migration, drug resistance, angiogenesis and lymphangiogenesis, and metastatization [5, 6]. This evidence concerns the gene EDN1 and neoplasm.