EDN1 and neoplasm: In particular, it has been described how β-arr1 bridges ET-1/ETAR axis to YAP signaling in high-grade serous ovarian cancer (HG-SOC) cells and in breast cancer cell lines harboring TP53 mutations, fostering the YAP/TAZ-dependent transcriptional program that confers upon tumor cells an invasive behavior [88, 97].