The first evidence of GPCR-dependent YAP/TAZ modulation reports that lysophosphatidic acid (LPA) and sphingosine-1-phosphate (SP1) receptors through the associated Gα12/13 and Gαq/11 may positively regulate YAP/TAZ activity in different human malignancies [69, 72, 73] promoting ovarian cancer cell migration [69] or hepatocellular carcinoma cell proliferation [73]. Here, YAP1 is linked to hepatocellular carcinoma.