EDN1 and breast cancer: In the nuclear compartment β-arr1 enrolls another oncogenic player, mutp53 protein, building up a transcriptional competent complex consisting of β-arr1/YAP/mutp53/TEAD that induces the aberrant expression of target genes, such as CTGF and CYR61. Notably, in breast cancer cells β-arr1 downstream of ET-1 may also coordinate the interaction of YAP/mutp53 with other active transcriptional factors, such as NFY, regulating its transcriptional repertoire, thus promoting cell proliferation [88, 97].