Interestingly, in mouse cardiomyocytes, used as study models for cardiovascular diseases, it has been described that CTGF represents an effector of the ET-1-induced fibrosis [92, 93], and in human lung fibroblasts CTGF is required for ET-1-induced alpha-smooth muscle actin (α-SMA) expression [94]. The gene discussed is EDN1; the disease is cardiovascular disorder.