This transport process promotes the activation of Wnt signaling pathway, increasing the expression of Wnt target genes, such as c-Myc [34], cyclin D1 [29], LGR5 [27], and MMP-7 [39] as well as regulate the proliferation, migration [40] and invasion [41] ability of NSCLC cells. The gene discussed is LGR5; the disease is non-small cell lung carcinoma.