Furthermore, a Phase Ib trial of a combination of lenvatinib and anti-PD-1 (pembrolizumab) in patients with unresectable hepatocellular carcinoma showed a good tolerability to combination therapy, promoting the initiation of a Phase III trial comparing the combination of lenvatinib + pembrolizumab with lenvatinib alone as a first-line treatment for advanced hepatocellular carcinoma [98]. This evidence concerns the gene PDCD1 and hepatocellular carcinoma.