TREM2 and early-onset autosomal dominant Alzheimer disease: Ab-T1 stains TREM2 in human Alzheimer’s disease brain tissue samples seen by immunohistochemistry staining (Fig. 2b panel), demonstrating its ability to recognize TREM2 in multiple patients with Alzheimer’s disease and co-localize with resident microglia (Iba1; Microglia) near beta amyloid plaques in entorhinal cortex.