To further confirm the relevance to the rodent models, Ab-T1 was shown to detect TREM2 in brains of 5xFAD Alzheimer’s disease mice (Fig. 2d) and co-localize with resident microglia (Fig. 2d; Microglia) and amyloid plaques (Fig. 2d; beta amyloid). This evidence concerns the gene TREM2 and early-onset autosomal dominant Alzheimer disease.