TGM2 and Dravet syndrome: The inclusion and exclusion criteria of the patients with DS and the prescribed medicines were different between the present study and the study by Dore et al. Type-2 transglutaminase (TGM2/TG2) is emerging as a multifunctional enzyme that is capable of promoting specialized enzyme functions under regulation by allosteric effectors depending on its cellular location such as angiogenesis, cell growth/differentiation, and cell death [17, 18].