The study also demonstrated that hsa_circ_0004104 may contribute to the pathogenesis of CAD by upregulating of atherosclerosis-susceptible genes, such as IDO1, MMP8, CD40, and downregulating of anti-atherosclerosis genes, such as ApoA I, RNASE1 [27]. This evidence concerns the gene RNASE1 and coronary artery disorder.