Since diverse abnormalities converge in the wall of blood vessels and alter BBB and SCBB in sALS, and vascular alterations are reported in animal models showing downregulation or overexpression of TDP43 it is tempting to speculate that TDP-43 vasculopathy contribute to the altered vascular function in sALS/FTLD-TDP43 spectrum. Here, TARDBP is linked to vascular disorder.