NPPB and hydrops fetalis: The possible cardiac toxicity of DAA drugs are supported by the data from Ahmed et al., which showed that treatment with BMS-986094 [a nucleotide analog of HCV nonstructural 5B-polymerase-inhibitor in interferon-free combinations with DCV and RBV] was stopped after a young male patient experienced rapidly progressive HF and passed away, and 41.2% of patients had some evidence of cardiac dysfunction, with a modest elevation of plasma levels of brain natriuretic peptide (BNP)—the sensitive marker of myocardial stress—in the majority of cases.