INS and Insulin resistance: AdipoRon also had no effects on body weight (Fig. 4a) nor food intake (Fig. 4b) in AdipoR1-humanized mice fed a high-fat diet, importantly, AdipoRon could significantly decrease plasma glucose levels (Fig. 4e) and plasma insulin levels (Fig. 4f) during OGTT and also insulin resistance index (Fig. 4g), indicating that AdipoRon could indeed ameliorate insulin resistance and glucose intolerance via human AdipoR1 in skeletal muscle.