Mounting evidence has shown that PFKFB3 expression is significantly higher in many cancers, including high-grade astrocytoma [7], head and neck squamous cell carcinoma [8], hepatocellular carcinoma [9], malignant pleural mesothelioma [10], breast and colon [11], gastric [12], thyroid [13], and ovarian cancer [14]. This evidence concerns the gene PFKFB3 and cancer.