When the concentrations of CBPt or Cis required to inhibit cancer cell growth by 50% (IC50) were compared with and without PFKFB3 KD, silencing PFKFB3 in chemoresistant HEC-1B and ARK-2 cell lines significantly reduced the average CBPt and Cis IC50s (Fig. 5c–f). Here, PFKFB3 is linked to cancer.