The combination of PFK158 with CBPt or with Cis acted synergistically to significantly decrease cell viability in vitro and inhibit tumor growth in two chemoresistant EC mouse xenograft models in vivo through induction of apoptosis, autophagy, disrupting DNA repair, and inactivation of the Akt/mTOR signaling pathway in EC (Fig. 8). This evidence concerns the gene AKT1 and neoplasm.