PRMT1 and colorectal carcinoma: We also found that PRMT1 enhanced CRC cell proliferation and metastasis via an EGFR-independent mechanism of asymmetric dimethylation of NONO at R251 that was independent of the presence of KRAS mutation, as the effect was observed in both KM12 cells expressing WT KRAS and KRAS-mutant HCT8 cells.