As a component of the cyclic (c)AMP signaling pathway, NONO was shown to interact with the long noncoding (lnc)RNAs LINC00473 and MetaLnc9 to facilitate transcription through cAMP-responsive element-binding protein (CREB) and CREB-regulated transcription coactivator to promote lung cancer growth and metastasis [14, 15]. Here, CREB1 is linked to lung carcinoma.