Acetyl heparan sulfate proteoglycan is a key component of the brain ECM and obviously increased in glioma [42], acting as a reservoir for heparin-binding angiogenic growth factors such as fibroblast growth factor and vascular endothelial growth factor [43], regulating tumor cell niche, angiogenesis, and invasion mechanisms [44]. The gene discussed is VEGFA; the disease is central nervous system cancer.