IRF1 and hematopoietic and lymphoid system neoplasm: Frequent loss-of-function mutations were also observed for CD58 [36], IGLL5 [37], IRF1 [38], LTB [39], MGA [40] and VMP1 [41] in blood cancers, implicating a potential tumour-suppressive role of these genes in the pathogenesis in this tissue type.