NCOA3 and breast cancer: Consistent with these studies, here, in extended cohorts of endocrine therapy treated populations, we observed worse distant metastasis free survival in tamoxifen treated patients and reduced breast cancer specific survival in AI treated patients harboring high AIB1 mRNA expression (P = 0.0002, N = 669; P = 0.0004, N = 70, respectively) (Figs. 1A, B; S1A, B).