Genome-wide analysis of the transcriptionally activating H3K4me3 mark in endocrine resistant metastatic tumors, revealed altered binding profiles in poor outcome patient tumors for EMT marker genes profiled in 5 A and genes encoding the top-ranked AIB1 interacting cell adhesion and cadherin binding proteins (Fig. S6A, B). This evidence concerns the gene NCOA3 and metastatic neoplasm.