Microcomputed tomography of metastatic long bones showed that the BV/TV ratio (a measure of the bone volume) was decreased (p = 0.035) in mice inoculated with MCF-luc2-ITGA5 cells, indicating a higher extent of bone destruction compared to animals bearing MCF-7-luc2-Ctrl tumor cells (Fig. 3E). Here, ITGA5 is linked to neoplasm.