We therefore silenced ITGA5 in claudin-low MDA-MB-231 and MDA-B02 breast cancer cells, the latter being a bone metastatic cell subpopulation of the MDA-MB-231 cell line, which constitutively and specifically overexpresses αvβ3 integrin compared to the parental cell line [17, 33]. The gene discussed is ITGA5; the disease is breast carcinoma.