To examine the potential contribution of ITGA5 in the homing of breast cancer cells to bone, we analyzed by immunohistochemistry ITGA5 protein levels in 268 radically resected primary tumors from a cohort of breast cancer patients with no clinical signs of metastasis for whom the presence or absence of DTCs in the bone marrow was documented (Table S2) [29]. The gene discussed is ITGA5; the disease is breast cancer.