LZTS2 and hepatocellular carcinoma: Importantly, compared to the re-expression of LZTS2-WT, the restoration of the siRNA-resistant LZTS2 mutant resulted in a greater decrease in the level of p-AKT, indicating that the β-Trcp and CK1δ-mediated destruction of LZTS2 stimulates the activation of PI3K/AKT signaling in HCC.