BTRC and hepatocellular carcinoma: More importantly, our rescue experiments illustrated that the LZTS2 mutant was more potent than wild-type LZTS2 in inhibiting the activation of PI3K/AKT signaling and impairing cell proliferation and metastasis, suggesting that β-Trcp and CK1δ-mediated LZTS2 degradation promotes tumorigenesis and metastasis by activating PI3K/AKT signaling in HCC.