Intriguingly, Tosi et al. reported that bone resorption was more prominent in patients with t(4;14) chromosomal abnormality [17], a karyotypically silent molecular abnormality that has been described in 10–20% of newly diagnosed MM and drives overexpression of MMSET and FGFR3 [18]. The gene discussed is NSD2; the disease is Miyoshi myopathy.