To determine whether targeting CREB relieves hypoxia-stimulated myeloma cell suppression of osteoblast (OB) differentiation in vitro, we knocked down CREB in myeloma cells using a lentivirus expressing shRNA, and we ensured that DKK1 expression was largely eliminated (Fig. 6a), but the MMSET protein stability was not obviously altered (Supplementary Fig. 4A). This evidence concerns the gene NSD2 and plasma cell myeloma.