CREB1 and Miyoshi myopathy: Exposure to hypoxia gradually enhanced CREB phosphorylation at Ser133 in diverse MM cell lines (Fig. 2c; and Supplementary Fig. 2B) and accelerated the cyto-nuclear translocation of CREB as detected by analysis of nuclear and cytoplasmic proteins (Fig. 2d) and immunofluorescence staining (Fig. 2e).