We previously reported the inhibitory effect of TAS4464 on the neddylation pathway in several hematopoietic cancers [27, 31], and in this study, a similar drug functionality of TAS4464 was shown in AML cell lines by confirming the decrease in NEDD8 conjugation by Ubc12 or cullin1 (Fig. 3A). This evidence concerns the gene UBE2M and acute myeloid leukemia.