Additional genes upregulated by CP2 in APP/PS1 mice included those involved in synaptic transmission and synapse assembly and that are known to be downregulated in AD patients, including glutamate receptor 4 (GRIA4), which mediates fast synaptic excitatory neurotransmission; metabotropic glutamate receptor 7 and 2 (GRMN7 and GRM2), which facilitates the formation of LTP; Double C2 protein (Doc2a), which contributes to spontaneous excitatory and inhibitory release; and Neurexins1 (NRXN1), which facilitates formation of functional synaptic structures (Supplementary Figs. 13e, 14h). This evidence concerns the gene GRM2 and Alzheimer disease.