NFKB1 and Other metabolic disease: Therefore, our studies showing the critical roles of lncRNA HOTAIR in NF-κB activation Glut1 expression and glucose uptake under LPS-induced inflammation in macrophages reveals a novel signaling pathway by which is lncRNAs may influence glucose metabolism and may induce metabolic reprogramming in macrophages during imflammation and immune response and therefore, this may serve as a novel therapeutic avenue in the treatment of inflammatory, immune, and metabolic disease.