FN1 and glomerulosclerosis: Lastly, these mice were also protected against the development of glomerulosclerosis and tubulointerstitial fibrosis as seen by decreased accumulation of collagens assessed using trichrome (Fig. 7A) and picrosirius red (PSR) staining (Fig. 7B), as well as decreased deposition of the extracellular matrix protein fibronectin, assessed by immunohistochemistry (Fig. 7C) and immunoblotting (Fig. 7D).