We compared the prognostic value of the immune prognostic index with other immune gene signatures for breast cancer including HRneg/Tneg signature linked to immune/inflammatory cytokine regulation (ABO, CLIC5, CXCL13, EXOC7, HAPLN1, MATN1, PRRG3, PRTN3, RFX7, RGS4, RPS28, SSX3, ZNF3, HRBL)16 and B cell response genes (IGK@[IGKC], GBP1, STAT1, IGLL5, and OCLN)27 in the discovery and METABRIC dataset. The gene discussed is RGS4; the disease is breast carcinoma.