PRRT2 and neoplasm: The 12-deoxyphorbol ester prostratin has been reported to reduce tumor volume in mouse models of pancreatic cancer44, but is only a weak modulator of PKC, while the activity of ingenol-3-angelate (marketed as ingenol mebutate or Picato used for treatment of actinic keratosis45,46 and basal cell carcinoma47) may also involve additional targets48.