ZNF154 and neoplasm: To test this hypothesis, we compared the frequency of methylation at probe cg21790626 (the CpG site we had previously determined to be the best ZNF154 methylation marker3,4) with the frequency of 52 mutations in cancer-associated genes for 11 solid tumor types from TCGA (N = 3691 for all tumor samples, N = 510 for all healthy tissue samples).