Each sample set of cancer patient plasma had a significantly higher concentration of methylated ZNF154 cfDNA fragments per mL than the normal controls (late-stage pancreatic cancer median normalized fragments = 19.47/mL plasma; ovarian cancer median normalized fragments = 27.30/mL plasma; normal controls median normalized fragments = 11.38/mL plasma) (Fig. 5A). Here, ZNF154 is linked to familial pancreatic carcinoma.