In SCC cells however, IL-33 is not secreted, but instead is translocated to the nucleus and functions there; in turn, nuclear IL-33 drives expression of immunosuppressive chemokines, such as Ccl5 and Cxcl10, and we showed that IL-33 functions exclusively downstream of FAK in promoting pro-inflammatory gene expression and tumor growth9. Here, CCL5 is linked to neoplasm.